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Monday, October 19, 2020 | History

4 edition of Health effects and dose-response assessment for hydrogen chloride following short-term exposure found in the catalog.

Health effects and dose-response assessment for hydrogen chloride following short-term exposure

Health effects and dose-response assessment for hydrogen chloride following short-term exposure

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Published by The Center in Research Triangle Park, N.C .
Written in English

    Subjects:
  • Air quality management -- United States,
  • Hydrogen chloride -- Testing

  • Edition Notes

    Other titlesHealth effects and dose response assessment for hydrogen chloride following short-term exposure
    Statementprepared for Air Risk Information Support Center, Office of Air Quality Planning and Standards, and Office of Health Evaluation Assessment, U.S. Environmental Protection Agency ; prepared by Clement International Corporation
    ContributionsAir Risk Information Support Center (U.S.), United States. Environmental Protection Agency. Office of Air Quality Planning and Standards, United States. Environmental Protection Agency. Office of Health Evaluation Assessment, Clement International Corporation
    The Physical Object
    FormatMicroform : final report
    Pagination1 v. (various pagings)
    ID Numbers
    Open LibraryOL14452273M
    OCLC/WorldCa31469227

    Hazard characterization: Dose-response determination (LD50/LC50, NOAEL, T25, EC50, NOEC, etc), determining the relationship between the magnitude of exposure to a hazard and the probability and severity of adverse effects. Exposure assessment: identifying the extent to which exposure actually occurs. Exposure levels are usually estimated or. the dose-response relationship (This is dose-response assessment and is also included in IRIS assessments.), and the extent of human exposure to those agents (This is exposure assessment.). The product of the risk assessment is a statement regarding the probability that populations or individuals so exposed will be harmed and to what degree.

    Given the litany of health effects associated with nitrate exposure and the uncertainty that this volume of evidence brings to the prediction of health risks, sound scientific judgment dictates that the U.S. EPA apply a safety factor of at least two to the current 10 PPM standard for nitrate-nitrogen in drinking water. National Research Council Subcommittee on Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants (development of health-protective short-term and long-term airborne levels for acetaldehyde, hydrogen chloride, hydrogen fluoride, hydrogen sulfide, and .

    Chlorine is a chemical element (symbol Cl) belonging to the halogen family, with an atomic weight of (White, ). In nature, chlorine is found only as the combined chloride ion (Cl-), with a valence of -1 (White, ).Chloride makes up much of the salt . Although the short-term health effects of formaldehyde exposure are well known, less is known about its potential long-term health effects. In , laboratory studies showed that exposure to formaldehyde could cause nasal cancer in rats. This finding raised the question of whether formaldehyde exposure could also cause cancer in humans.


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Health effects and dose-response assessment for hydrogen chloride following short-term exposure Download PDF EPUB FB2

Get this from a library. Health effects and dose-response assessment for hydrogen chloride following short-term exposure: final report. [Air Risk Information Support Center (U.S.); United States. Environmental Protection Agency. Office of Air Quality Planning and Standards.; United States.

Environmental Protection Agency. Office of Health Research. The numbers in these tables support hazard identification and dose-response assessment, as defined in the National Academy of Sciences (NAS) risk assessment paradigm, for estimating the risk of contracting cancer and the level of hazard associated with adverse health effects other than cancer.

Health effects and dose-response assessment for hydrogen chloride following short-term exposure: final report (Book) 5 editions published between and in English and held by WorldCat member libraries worldwide.

Assessment of Acute or Short-Term Exposures. Risk assessments are also conducted to derive permissible exposure levels for acute or short-term exposures to chemicals. Health Advisories (HAs) are determined for chemicals in drinking water.

HAs are the allowable human exposures for 1 day, 10 days, longer-term, and lifetime durations. HYDROGEN chloride (HCl) is a colorless, corrosive gas with a pungent, suffocating odor.

It is highly soluble in water, forming hydrochloric acid. HCl can occur in gaseous and aerosol forms in the atmosphere, and its partitioning between the two is dependent on. HYDROGEN chloride (HCl) is a colorless, corrosive gas with a pungent, suffocating odor.

It is highly soluble in water, forming hydrochloric acid. HCl can occur in gaseous and aerosol forms in the atmosphere, and its partitioning between the two is dependent on temperature and humidity (Sebacher et al.

Lower ambient temperature and higher relative humidity in the atmosphere favor aerosol. Ricardo Ochoa, in Fundamentals of Toxicologic Pathology (Third Edition), Dose–Response Assessment.

Dose–response assessment is a critical element of hazard characterization. Nonclinical toxicity studies are designed to evaluate the conditions under which exposure to the test article might induce an effect, and particularly an adverse effect (i.e., “toxicity”). PatrickHealth effects and dose-response assessment for hydrogen chloride following short-term exposure () Prepared for Air RISC Information Center, U.S.

Environmental Protection Agency, Clement Int. Corp., K.S. Crump Division, Ruston, LA. THIS chapter focuses on dose-response analysis and its role in choosing a point of departure to be used in the risk assessment for MeHg. The chapter begins with a brief review of risk assessment for noncancer end points.

Problems with the traditional approach that is based on no-observed-effect levels (NOAELs) will be discussed, along with advantages of more recent approaches that are based on. a risk assessment need to consider the hazard identification and dose-response parts of the risk assessment in the planning stages of the exposure assessment so that these three parts can be smoothly integrated into the risk characterization.

Health effects and dose-response assessment for hydrogen chloride following short-term exposure. of dose-duration-response information for short-term exposure to hydrogen chloride.

The. Dose-Response Curves (1) •No observed effect level (NOEL) –The highest tested dose of a substance that has been reported to have no harmful (adverse) health effects on people or animals. •No observed adverse effect level (NOAEL) –It denotes the level of exposure of an organism, found by experiment or observation, at which there is no.

No studies concerning the long-term effects of short- term, high-level exposures have been reported. Long-term exposure to hydrogen chloride (presumably above 45 mg/m 3 (30 ppm)) reportedly erodes the teeth, especially the incisors.

Although some evidence of acquired sensory tolerance in long-term exposures has been reported, the Task Group. The following resources provide more information on the safety and health effects of hydrogen sulfide: Hydrogen Sulfide (H 2 S).

OSHA Fact Sheet, (October ). Provides a concise list of industrial sources, symptoms and health effects of exposure to hydrogen sulfide, and OSHA requirements for the protection of workers.

Hydrogen Sulfide (H 2 S. PREFACE The Office of Health and Environmental Assessment has prepared this health assessment to serve as a source document for use by the Office of Air Quality Planning and Standards to support their information needs on the health effects of mercuric chloride, which is listed as a hazardous air pollutant in the Clean Air Act Amendments of EPA///F December Summary Review of Health Effects Associated with Hydrogen Fluoride and Related Compounds Health Issue Assessment Environmental Criteria and Assessment Office Office of Health and Environmental Assessment Office of Research and Development U.S.

Environmental Protection Agency Research Triangle Park, NC For sale by the Superintendent. to separate health effects by route of exposure. As noted previously, epidemiology studies have relied on internal dose metrics (PbB, bone Pb), which reflect Pb body burden (to varying degrees), irrespective of the route of exposure.

The primary systemic toxic effects of Pb are the same regardless of the route of entry into the body. Interval Censoring And Marginal Analysis In Ordinal Regression.

Health effects and dose-response assessment for hydrogen chloride following short-term exposure. associated with short-term. Hydrogen chloride (HCl) is a colorless gas with a pungent, suffocating odor. It is used in the manufacture of organic and inorganic chemicals, oil-well acidizing, steel pickling, food processing, and minerals and metals processing.

For short-term exposure to x-rays, gamma radiation or beta (electron) radiation, the dose equivalent (rem or sievert) is the same as the absorbed dose (rad or gray).

Communicating the real health effects of radiation would remove many of the objections to the construction of nuclear power plants. TIME COURSE: Effects occur rapidly following exposure to respiratory symptoms may be delayed in onset.

EFFECTS OF SHORT-TERM (LESS THAN 8-HOURS) EXPOSURE: Ammonia is a severe irritant of the eyes, respiratory tract, gastrointestinal (GI) tract, and reacts with the moisture in the moist linings of body passages and cavities (mucous membranes) to produce an alkaline .such as cancer or respiratory effects.

Step 2 - Dose-Response Assessment The risk assessor characterizes the relationship between a person’s exposure to a pollutant and the occurrence of an adverse health effect.

Step 3 - Exposure Assessment The risk assessor estimates the extent of public exposure by looking at who is likely to be exposed.2. Exposure assessment −Measure or estimate the intensity, frequency, and duration of human exposure to the agent 3.

Dose-response assessment −Characterize the relationships between varying doses and incidences of adverse effects in exposed populations 4. Risk characterization −Estimate the incidence of health effects under the.